Wanna collaborate with us?
We are always interested by highly motivated young scientists at the Master, PhD and Post-doctoral level! Applicants with an international research experience and strong background in molecular biology/immunology/developmental biology/bioengineering are encouraged to apply. You will be most welcome in a young, friendly and dynamic environment. See below positions detailed. Please provide your CV, motivation statement and up to 3 referees at: paul.bourgine@med.lu.se
GENERAL INFORMATION
The lab: The successful candidates will be part of the novel laboratory for Cell, Tissue and Organ engineering. The laboratory is part of the Wallenberg Centre for Molecular Medicine (WCMM LU), at the Lund Faculty of Medicine (https://www.med.lu.se/english). Focusing on regenerative medicine (regeneration, replacement and repair), WCMM LU is part of a national effort to strengthen Sweden as a world-leading life science nation (https://www.med.lu.se/wcmm).
Our lab aims at deciphering the cellular & molecular mechanisms occurring during phases of bone formation/repair. Using state-of-the-art 3D culture systems, death-inducible human mesenchymal lines and tissue engineering protocols, we focus on studying processes of cartilage/bone/bone marrow establishment in human(ized) contexts. Compiled knowledge will be used for the design of cell-based but cell-free extracellular matrices, to be used as smart-materials for skeletal repair. As such, the lab covers both fundamental and translation research aspects. More information available on our website: www.bourginelab.com
The University: The lab located within the BioMedical Center at the Faculty of Medicine, and is part of Lund University (Sweden). The university was founded in 1666 and is repeatedly ranked among the world’s top 100 universities. Lund University has 42 000 students and 7 400 staff based in Lund, Helsingborg and Malmö. The Faculty of Medicine as part of Lund University is responsible for education and research within medicine and healthcare. Our academic programs are closely linked with the healthcare system and are firmly anchored in the faculty’s strong research tradition. Our research spans a broad field within experimental preclinical research, near-patient clinical research and health sciences research. The Faculty of Medicine, with its 1,800 employees and 2,700 students in Lund and Malmö, is a knowledge-intensive meeting place for students, teachers and researchers from all over the world. Easily accessible via Copenhagen airport (35min), Lund is a dynamic and well-connected city in the heart of the Scandinavian hub.
MASTER PROJECTS
The lab has hosted Master students from all over the world and we always seek for young and dynamic new members. We encourage students with a background in engineering, bioinformatics, cell biology, or biomedicine to apply.
OPEN RESEARCH ASSISTANT/ENGINEER POSITION (#001):
Manufacturing and characterization of human tissues
The position: The candidate will be involved in routine lab management/organization, as well as in the generaon of human bone/marrow organoids. Those will be generated on a regular basis according to our established protocol (see Grigoryan et al., Science Translational Medicine 2022). Other tasks can be implemented according to the candidate profile/expertise, and his/her interest in learning new techniques. That could include animal work or characterization of engineered human tissues.
Ideal profile: The candidate should have the capacity to integrate and work in an international environment, and have robust English speaking/writing skills. Solid knowhow of Microsoft office tools is required as well as an experience with cell culture (adherent cells). In addition, the following skills are considered a clear added value: robust Swedish speaking/writing skills, experience in the field of stem cells (mesenchymal/hematopoietic systems), animal experimentation or histology techniques. The capacity to use the Lupin/ordering system is a plus.
Employment type: 60 to 100%, negotiable
Starting Date: Early 2024, best before March 2024
Duration: minimum 1 year, renewable
OPEN POSTDOCTORAL POSITIONS (#002):
In vivo engineering of human hematopoietic stem cell niches
The position: We are seeking for a candidate with a high and healthy ambition to discover! The successful candidate will hold a postdoctoral position for two years (renewable) funded by an ERC Starting grant. The project will consist in exploiting the human ossicle technology to form molecularly customized niches in mice. Those will be exploited under two axes:
(i) increase the development and functionality of engrafted human hematopoietic cells in human ossicles
(ii) study the engraftment of AML/MDS patient materials and the corresponding impact of the human niche in disease progression
Ideal profile: You possess a PhD degree in biology or equivalent and a strong background in cell and molecular biology applied to mesenchymal stem cells and/or hematopoiesis. You have robust experience in flow cytometry, confocal microscopy techniques, cell culture, animal experimentation. Previous experience on the engineering of humanized mice or on the study of the bone marrow niche in malignant context is a strong asset. Experience in molecular cloning, spatial-transcriptomic or scRNA transcriptomics is a plus.